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  • Life Sciences

Investigating cell biological effects

Advanced in vitro test methods: from mechanism of action to quality control

Prove efficacy. Ensure safety.

Advanced in vitro test methods enable scientifically sound evaluation of bioactive substances. In controlled cell culture experiments, we characterize and test your substances, provide mechanistic insights into modes of action, and establish the evidence base for product development, regulatory approval, and market communication.

Overview of our services

  • Cellular Test Systems:
    - Customized cell models for a wide range of organ systems: skin and mucous membranes, gastrointestinal tract, musculature, nervous system, blood cells, and bone and cartilage
  • Physiological Endpoints: 
    - Cell-based efficacy assessments: differentiation, proliferation, cytoprotection, angiogenesis, energy metabolism (GLP-1, AMPK, glucose uptake), and receptor binding studies (ERα/ERβ, FXR, TRPV, 5-HT1A)
  • Antioxidant & Anti-Inflammatory Capacity:
    - FluoroScan screening for intracellular radicals; complemented by GSH redox status and inhibition of inflammatory cytokines (IL-6, IL-8, TNFα)
  • Genotoxicity:
    - DNA strand break screening via automated FADU assay; complemented by Ames test, Comet assay, and micronucleus assay for REACH, botanicals (THMP), and cosmetics
  • Biocompatibility Testing (ISO 10993):
    - Cytotoxicity (ISO 10993-5)
    - Skin irritation (ISO 10993-23 / OECD TG 439)
    - Skin corrosion (OECD TG 431)
    - Sensitization (ISO 10993-10 / OECD TG 442C & 442D)
  • Bioavailability:
    - Transepithelial transport in the Caco-2 model with optional upstream gastrointestinal simulation; cell-free determination of passive permeation via PAMPA
  • Particle Characterization (DLS):
    - Determination of particle size, zeta potential, and polydispersity index (0.3 nm–10 μm) for quality assurance of galenic formulations

Our Experts:

Bioarray Bioarray 
Microbiological hygiene and air purification for maximum safety. Learn more

The industries:

  • Life Science
  • Pharma
  • Medical devices
  • Scientific community
  • Food / agri Producers​
  • Consumer goods producer​
  • CRO​
  • Cosmetics